Tuberculosis vaccine development :The development of a novel (preclinical) DNA vaccine
نویسندگان
چکیده
منابع مشابه
Veterinary tuberculosis vaccine development.
Tuberculosis caused by Mycobacterium bovis in domestic livestock and wildlife is a significant problem in many countries worldwide. Wildlife reservoirs of tuberculosis confound programs for tuberculosis eradication from domestic livestock. Successful vaccination against tuberculosis in domestic animals or wildlife could contribute to tuberculosis eradication. Bacille Calmette-Guérin (BCG) has b...
متن کاملCurrent tuberculosis vaccine development.
Information derived from the complete genome sequence of Mycobacterium tuberculosis makes it possible to develop a range of new vaccine candidates. Strategies currently under investigation include construction of whole cell live attenuated mycobacterial vaccines, as well as the use of individual antigens delivered by a variety of subunit vaccination procedures. Fundamental questions associated ...
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Objective(s): Mycobacterium tuberculosis (M. tuberculosis), an intracellular pathogen, causes 1.5 million deaths globally. Bacilli Calmette-Guérin (BCG) is commonly administered to protect people against M. tuberculosis infection; however, there are some obstacles with this first-generation vaccine. DNA vaccines, the third generation vaccines, can induce cellular immun...
متن کاملAdjuvants in tuberculosis vaccine development.
Tuberculosis remains a major public health problem around the world. Because the Mycobacterium bovis Bacilli-Calmette-Guerin (BCG) vaccine fails to protect adults from pulmonary tuberculosis, there is an urgent need for improved vaccine formulations. Unlike BCG, recombinant vaccines purified from bacterial expression vectors, as well as naked DNA, require an additional adjuvant. Recent improvem...
متن کاملTuberculosis Vaccine: Historical Perspec- tives on Tuberculosis Prevention and Novel Approaches to Vaccine Development
Tuberculosis | www.smgebooks.com Copyright Costa C.This book chapter is open access distributed under the Creative Commons Attribution 4.0 International License, which allows users to download, copy and build upon published articles even for commercial purposes, as long as the author and publisher are properly credited. Gr up SM Tuberculosis Vaccine: Historical Perspectives on Tuberculosis Pr...
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ژورنال
عنوان ژورنال: Human Vaccines
سال: 2010
ISSN: 1554-8600,1554-8619
DOI: 10.4161/hv.6.4.10172